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The numerous cellular RNAs that do not encode proteins but function directly in diverse cellular processes (a.k.a. non-coding RNAs) are one of the most exciting areas of research in biology today. Our appreciation of the numbers and importance of these RNAs has exploded in recent years. Non-coding (nc)RNAs include telomerase, microRNAs, viroids, and snoRNAs as well as snRNAs, tRNAs and rRNAs. Most of these RNAs function as part of RNA-protein complexes. Our lab studies the biogenesis, assembly, trafficking, and function of ncRNA-protein complexes (ncRNPs). Our work has direct links to the etiology and treatment of human disease including cancer, spinal muscular atrophy and dyskeratosis congenita, and to the development of both anti-microbial and gene therapy agents.
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RNA-protein complexes (assembly, transport and function), cancer, telomerase, RNA interference (RNAi), non-coding RNAs, antibiotics, virus defense
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