|
There are many small cellular RNAs that do not encode proteins, but function as part of RNA-protein complexes to carry out diverse essential processes. We are studying the biogenesis, transport and function of several important RNA-protein complexes (RNPs). Some of the RNPs that we study are directly involved in human diseases including cancer, dyskeratosis congenita, spinal muscular atrophy and Prader-Willi syndrome. Others function in novel RNA interference (RNAi) pathways with tremendous biotechnological and biomedical potential. In addition, our findings have immediate practical application in the design of RNA-based gene therapy agents that function effectively in cells.
|
|
|
cancer, telomerase, RNA-protein complexes (assembly, transport and function), gene therapy, non-coding RNAs, RNA interference (RNAi), ribozymes, spinal muscular atrophy, small nucleolar RNPs (snoRNPs)
|
